Introduction
Are you seeking alternative solutions for pain management beyond traditional options such as paracetamol (acetaminophen), NSAIDs (like ibuprofen and aspirin) and other prescription medications? If so, exploring the potential of supplements may be an option.
Throughout this exploration, we will delve into the realm of natural pain relievers and anti-inflammatories, discovering the potential benefits of a variety of compounds such as White Willow, D-Phenylalanine (DPA), Palmitoylethanolamide (PEA), Cannabidiol (CBD), Curcumin, Omega-3s, Glucosamine and Low-Dose Naltexone (LDN).
Discuss your pain management approach by consulting with a healthcare professional before incorporating any of these supplements into your regimen or combining them with your current medication. This article does not provide medical or professional advice.
White Willow
White Willow is a tree native to Europe and Asia that has been used for centuries in traditional medicine as a natural remedy for pain and inflammation. The bark of the white willow tree contains salicin which is converted into salicylic acid in the body. It can be considered a natural form of acetylsalicylic acid or aspirin, and has similar pain-relieving and anti-inflammatory effects. Interestingly aspirin was developed from White Willow in the first place.
Unlike non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin, white willow bark may have a lower risk of causing gastrointestinal side effects and is considered generally safe, however excessive doses may have similar side effects to aspirin so caution in advised.
White willow bark can be used to treat a variety of conditions including headache, menstrual cramps, osteoarthritis, and back pain. However, it is important to note that white willow bark should not be used in place of traditional medical treatments without consulting a healthcare professional. It is important to note that white willow should not be taken with certain other medications, especially other NSAIDs like ibuprofen or aspirin.
D-Phenylalanine (DPA)
DPA is a form of the amino acid phenylalanine that can be used to manage pain and improve mental health. It works by blocking the breakdown of endorphins and enkephalins, the body’s natural pain-relieving compounds, leading to an increase in their levels and a reduction in pain.
Unlike opioids, DPA is considered safe and non-addictive, with a low risk of adverse side effects. This is believed to be partly due to its ability to increase levels of endogenous opioids that bind to a broad range of opioid receptors, including μ (mu – the traditional target of opioids), δ (delta – which is also anti-depressant), and others.
It may have beneficial effects on various types of pain, including chronic pain, neuropathic pain, fibromyalgia, arthritis and headaches. DPA has also been shown to have benefits for mood, stress, and anxiety, and may have potential for treating other diseases as well.
DPA is similar to Low-Dose Naltrexone (LDN) in that they both block the breakdown of enkephalins and endorphins, modulate the immune system and the activity of the nervous system, but it is not known for certain whether DPA can help treat every condition that LDN treats.
There is also another supplement called DLPA (D,L-Phenylalanine) which is a combination of the D-form and L-form. L-phenylalanine (LPA) is an essential amino acid that the body uses to synthesize neurotransmitters, including dopamine and norepinephrine, which play a role in mood regulation and can increase energy. It is more available than DPA but it is stimulating so if you use this form it is better to take it earlier in the day.
DPA reportedly converts to LPA in small amounts so people with phenylketonuria (PKU), a genetic disorder that affects the metabolism of phenylalanine, should avoid taking D- or L-phenylalanine supplements as it can lead to harmful elevations of phenylalanine levels in their blood.
Finally, it is crucial to consult with a healthcare professional before taking these supplements, as it can interact with certain medications and health conditions.
Palmitoylethanolamide (PEA) and Cannabidiol (CBD)
PEA is a naturally occurring fatty acid amide that has been found to have potent anti-inflammatory and analgesic properties. It works by regulating the activity of the nervous system and reducing the release of pro-inflammatory substances in the body. PEA is not related to cannabis, but has been shown to have similar effects on the body’s pain response system without producing a psychoactive effect. It can be used to treat a variety of conditions including neuropathic, arthritic, and inflammatory and chronic pain, lower back pain, headache, (1) and even depression and anxiety (2).
Unlike some pain medications, PEA is non-toxic and is produced in small amounts in the human body, and generally does not produce any adverse side effects, making it a promising alternative for those seeking a safe and natural approach to pain management.
CBD, a compound derived from hemp and cannabis plants, has been gaining popularity for its potential pain-relieving properties. It interacts with the body’s endocannabinoid system, which helps regulate pain, inflammation, and other physiological processes. When combined with THC, the pain-relieving effects of CBD are potentiated. However, THC is not legal in all jurisdictions and can produce unwanted psychoactive effects.
For those seeking an alternative, PEA has shown promise. In fact, a recent study found that CBD-containing hemp oil and PEA had a greater-than-additive effect on pain relief. This could be an attractive option for those who can’t access THC or do not like the side effects. (3)
When used topically as a cream, CBD on its own has shown to be effective for neuropathic and radicular pain. (4) However, the appropriate oral dosage for pain relief with CBD alone is not well established and at best has modest effects.
In addition to pain relief, CBD has also been shown to be beneficial for a variety of conditions, including anxiety, depression, epilepsy, multiple sclerosis, as well as sleep problems associated with chronic pain conditions, and more without any psychoactive effects associated with cannabis use.
However, more research is needed to fully understand the potential benefits and risks of using CBD for these conditions. It is important to note that the quality and efficacy of CBD products can vary widely, so it is always recommended to consult with a healthcare professional and choose high-quality products when using CBD for pain relief or any other health condition.
Curcumin
Curcumin, a compound found in turmeric, has powerful anti-inflammatory and pain-relieving effects. It works by inhibiting the production of pro-inflammatory cytokines and enzymes, reducing pain and inflammation. Curcumin supplements, which often contain high-quality and easily absorbable forms of the compound, are typically much more effective than regular turmeric.
In terms of pain relief, studies have shown that curcumin can be as effective as ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs), but with a lower risk of side effects such as gastrointestinal problems.
Beyond pain relief, curcumin has also been shown to be beneficial for a variety of conditions, including osteoarthritis, rheumatoid arthritis, heart disease, depression, and many others.
However, it is important to consult with a healthcare professional before taking curcumin, as it can interact with some medications such as blood thinners, diabetes medications, chemotherapy drugs, other anti-inflammatories and statins; as well as gallbladder conditions, bleeding disorders, iron deficiency, and surgeries.
Omega 3 fatty acids
Omega-3 fatty acids, found in fish oils and other sources, have been shown to have anti-inflammatory properties that can help relieve pain.
Omega-3s work by reducing the production of pro-inflammatory cytokines and increasing the production of anti-inflammatory molecules, leading to reduced pain and inflammation.
A safe and effective daily dose of omega-3s for pain relief is typically around 2-3 grams, but it is important to consult with a healthcare professional to determine the appropriate dose for an individual’s specific needs.
In terms of pain relief, omega-3s have been shown to be as effective as ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) in some studies (5), but without the risk of side effects such as gastrointestinal problems.
Omega 3s can be particularly useful when it comes to reducing inflammation caused by joint swelling or other inflammatory diseases such as lupus or rheumatoid arthritis. Taking omega 3 supplements regularly can help decrease joint stiffness and improve overall mobility.
It is important to note that taking high doses of omega-3s can increase the risk of bleeding and interact with certain medications, so it is always recommended to consult with a healthcare professional before supplementing with omega-3s for pain relief.
Glucosamine & N-Acetyl-Glucosamine
Glucosamine and N-acetyl-glucosamine (NAG) are natural compounds found in the human body and also in some foods.
Glucosamine is commonly used as a dietary supplement to help relieve joint pain and improve joint function. It works by providing the building blocks needed for the formation and repair of cartilage, a flexible tissue that cushions the joints.
NAG is similar to glucosamine and is believed to have similar benefits, but it is less well researched. NAG is also helpful for digestive and skin health. The main difference between the two is that NAG is more readily absorbed by the body and does not require conversion to be used by the body, whereas glucosamine must be converted.
Both glucosamine and NAG are generally considered safe when taken as directed, but it is always best to talk to a doctor before starting any new supplement regimen.
Low-Dose Naltexone (LDN)
Low Dose Naltrexone (LDN) is a unique pain reliever that works by blocking the opioid receptors in the body at low doses, leading to an increase in the release of endorphins, which are natural pain-relieving compounds. LDN is included this in a list of natural pain killers due to its effect on the endogenous opioid system in the body.
Unlike opioids, LDN is considered safe and non-addictive, with a low risk of adverse side effects. LDN has been shown to be effective for a variety of conditions, including chronic pain, autoimmune disorders, Crohn’s disease, multiple sclerosis and mental health conditions such as depression and anxiety.
LDN works differently than opioids and other pain relievers, and has been shown to be effective for many conditions where traditional pain medications may not be as effective. It is important to note that LDN is still considered a relatively new and experimental treatment, and more research is needed to fully understand its potential benefits and side effects.
However, many people have reported significant improvement in their pain and other symptoms when using LDN, making it a promising alternative for those seeking to manage their pain and improve their quality of life.
Please note that LDN is a medication not a supplement, but some doctors that know about its benefits are willing to prescribe it for a variety of health conditions due to its effectiveness and favourable safety profile compared to opioids and other medications used to treat the same conditions.
Conclusion
Natural alternatives such as Palmitoylethanolamide (PEA), White Willow, D-Phenylalanine (DPA), Curcumin, Omega-3s, Cannabidiol (CBD), Glucosamine and Low Dose Naltexone(LDN) provide safe yet effective solutions for those seeking alternative treatments for their chronic pains due to injury or illness.
While each one may work differently on different people depending on their condition , incorporating one or more into your daily routine could bring relief while avoiding potentially harmful side effects associated with opiates or other pain relievers. Always research each one thoroughly and speak to your doctor first before use. Good luck!
